Effect of serum on the yield of lymphocytic choriomeningitis virus in baby hamster kidney cells.

Lymphocytic-choriomeningitis virus in hamster tumor: spread to hamsters and humans.

A passage line of a spontaneous hamster fibrosarcoma is contaminated by the virus. of lymphocytic choriomeningitis. Tumors from animals receiving implants when newborn contain high titers of infectious lymphocytic-choriomeningitis virus and complement-fixing antigen, and hamsters receiving implants when weanlings develop high titers of complement-fixing antibody against lymphocytic-choriomening...

Lymphocytic Choriomeningitis in the Syrian Hamster

The virus of lymphocytic choriomeningitis produces an intense systemic infection in Syrian hamsters with few if any clinical and pathological signs of disease. Specific soluble antigen is demonstrable in the spleen of infected animals until about the 14th day when antisoluble substance antibodies make their appearance. Circulating virus disappears after the 4th week and neutralizing antibodies ...

Comparative attenuation of African horsesickness virus in mosquito (Aêdes albopictus) and in hamster kidney (BHK-21) celllines

An anti-lymphocytic choriomeningitis virus ribozyme expressed in tissue culture cells diminishes viral RNA levels and leads to a reduction in infectious virus yield.

Ribozymes, RNA molecules which cleave RNA in a sequence-specific manner, are a promising tool in the development of specific antiviral therapies. The viruses most susceptible to ribozymes may be those in which all aspects of the viral life cycle depend on RNA, with no DNA intermediate. Consequently, we have chosen as a model one such virus, the arenavirus lymphocytic choriomeningitis virus (LCM...

Pet Rodents and Fatal Lymphocytic Choriomeningitis in Transplant Patients

In April 2005, 4 transplant recipients became ill after receiving organs infected with lymphocytic choriomeningitis virus (LCMV); 3 subsequently died. All organs came from a donor who had been exposed to a hamster infected with LCMV. The hamster was traced back through a Rhode Island pet store to a distribution center in Ohio, and more LCMV-infected hamsters were discovered in both. Rodents fro...